New thematic dataset for discovering the role of IDPs/IDRs on Age-diseases

Age-related diseases are common worldwide conditions affecting adults and are often caused by the dysregulation of proteins associated with multiple biological systems. Here, we introduce a new thematic dataset: Age-related Disorders Proteins.

Our dataset currently focuses on intrinsically disordered proteins (IDPs) that are well-known for their involvement in neurodegenerative diseases (NDDs). Proteins were extracted from a curated database NDDvarbase, which includes entries related to 37 different NDDs. This dataset highlights some of the most notable proteins, including:

• DP00070 - Alpha-synuclein, encoded by the gene SNCA, with a disorder content of 99.3%. This protein is crucial for amyloid fibril formation and is responsible for Lewy body dementia.

• DP01248 - Vesicle-associated membrane protein-associated protein B/C, an endoplasmic reticulum (ER)-anchored protein primarily involved in Amyotrophic Lateral Sclerosis (OMIM#608627) and Spinal Muscular Atrophy, late-onset Finkel type (OMIM#182980).

Thanks to the dedicated efforts of expert DisProt biocurators—Victoria M. Nugnes, Federica Quaglia, and the DisProt Consortium —the dataset now features 45 proteins supported by over 306 pieces of evidence extracted from 115 scientific publications.