DisProt 2022_12 - Release featuring a thematic dataset of neglected tropical diseases IDPs and IDRs

The DisProt curation team is pleased to release a new thematic dataset portraying “Neglected tropical diseases proteins”, describing the presence and role of IDPs and IDRs in pathogens causative of these diseases.

Written on Dec 20, 2022, by Victoria Nugnes.

New thematic dataset of intrinsic disorder in Neglected tropical diseases proteins

The neglected tropical diseases (NTDs) are a subset of infectious diseases that are mainly prevalent in tropical areas, where they mostly affect impoverished communities. The variety of pathogens responsible for NTDs is represented in our dataset.

Examples from the “Neglected tropical diseases proteins” dataset include:

  • viruses e.g. Rabies virus Phosphoprotein, DP03566; Dengue virus Non structural protein 5, DP03809
  • bacteria e.g. Chlamydia trachomatis Translocated actin-recruiting phosphoprotein, DP01472
  • protozoa e.g. Trypanosoma cruzi SBDS-like protein, DP00957; Leishmania donovani HASPA protein, DP03871
  • fungi e.g. Madurella mycetomatis Pea pathogenicity protein 2, DP03786
  • helminths e.g. Schistosoma mansoni MEG-14, DP01970; Schistosoma haematobium Serine protease inhibitor, DP03791

The Neglected tropical diseases proteins dataset release features 82 entries and more than 125 pieces of evidence, annotated from more than 100 new articles not present in DisProt yet. We are grateful to our biocurators Julian Bergier, Jaime Santos Suárez, Edoardo Salladini, Juliet Nilsson, Pedro Pereira and Galo Balatti for their remarkable commitment and effort.